Endometriotic Exosomes Suppress Immune Defense and Promote Ectopic Tissue Survival
In a study published in the Journal of Immunology, Björk et. al investigated how NKG2D-mediated cytotoxicity affects the function of endometrios cells enviroment in endometriosis, highlighting its role in disease progression and its potential as a target for therapeutic intervention. This study explores the role of exosomes secreted by…
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A Key Modulator of Natural Killer Cell Dysfunction in Endometriosis: Soluble MICA
In a study published in the American Journal of the Reproductive Immunology, Abrao et al. investigated the potential effect of MHC Class I related MICA molecules at the pathogenesis of the endometriosis. This study highlights a novel role of soluble MICA (sMICA) in endometriosis, showing…
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By Selma OransayPeritoneal endometriosis and Peritoneal Immunity
By Selma Oransay
The peritoneum is an important immune barrier where, under normal conditions, it is balanced. External stimuli cause pro-inflammatory responses. To bring balance to this undesired situation, anti-inflammatory factors come into play. However, in patients with endometriosis, cytotoxicity of T lymphocytes,…
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By Bahar YukselHarnessing the Power of the Immune System: The Potential of Immunotherapy for Treating Endometriosis
By Bahar Yuksel
The review article by Wenshu Li et al. discusses the potential of immunotherapy as a novel treatment for endometriosis and the potential to overcome possible side effects and recurrence rates related to conventional therapies. The article explains how immunotherapy, which…
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Insights into immune dysfunction in endometriosis - Chandrakant Tayade, DVM, PhD
By Bahar Yuksel
In his speech presented at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2, 2023, Dr. Tayade talks about the relationship between endometriosis and the immune system. Dr. Tayade begins by emphasizing the significance of…
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Machine learning based potential biomarkers
By Bahar Yuksel
To explore potential biomarkers for an accurate diagnosis and treatment, and to elucidate the mechanism of endometriosis, Yi Huang et al, analyzed gene differences between eutopic and ectopic endometrium and the status of the immune microenvironment., and published their results in the…
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By Eylül GÜNA new potential therapeutic target in endometriosis: Galectin-3
By Eylül GÜN
The endometrial cells migrate and attach to the peritoneal surface according to the most widely accepted retrograde menstruation theory in endometriosis development. Given that only 10% of women have endometriosis, it is thought that some additional factors contribute to the…
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By Dr. Youngran ParkEndometriosis and Natural Killer Cell Immunity
By Dr. Youngran Park
It is known that approximately 25 to 50% of infertile women have endometriosis, and 30% to 50% of the women with endometriosis have infertility and recurrent pregnancy loss. Previous studies have shown that women suffering endometriosis have abnormal NK cell…
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Immune cells and endometriosis pain
By Dr. Youngran Park
Endometriosis is an estrogen-dependent inflammatory disorder in women. This disease leads to dysmenorrhea, pelvic pain, and infertility. The immune reaction is one of the most widely accepted pathologies of endometriosis. Estrogen dysfunction stimulates immune cells in the peritoneal cavity affecting…
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By Yu YuNatural killer cells receptor expression in endometriosis
By Yu Yu
Increasingly, studies have reported that endometriosis pathogenesis is related to defect in immune functions. The data also points to the impaired function of natural killer (NK) cells, leading to less cytotoxic NK cell activity in endometriosis. Similar to B and…
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Therapeutic potential of ginseng based compound in preclinical models of endometriosis
By Yu Yu
Currently, the drug option for women with endometriosis mainly focus on reducing estrogens levels (e.g., progestins, androgens, gonadotropin-releasing hormone (GnRH) agonists, and aromatase inhibitors). However, these therapies can have low effectiveness with frequent recurrence and considerable side effects. Therefore, there…
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By Murat OsmanOxidative Stress and Endometriosis
By Murat Osman
Endometriosis is a disease characterized by ectopic endometrial tissue outside the endometrium and is associated with a background of a chronic inflammation. Recent studies have aimed to elucidate the inflammatory mediators involved in endometriotic lesions by studying immune cell interactions,…
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By Özge ÖzkayaThe Chance of Getting Pregnant of a Woman with Endometriosis May Soon Be Predictable
By Özge Özkaya
Researchers have found a new way of predicting whether or not an embryo will be able to successfully implant into the womb of a woman with endometriosis. These findings could make it possible to predict whether she is likely to…
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By Demet Candaş GreenRole of immune cells in endometriosis
By Demet Candaş Green
Immune cells have essential functions in the body such as detection and clearance of abnormal cells and debris. One of the possible mechanisms for the development of endometriosis is proposed to be the impaired function of immune system cells in…
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